Assessing the risk of transplant rejection is a basic component of clinical decision-making, whenever a transplant recipient visits you or other healthcare providers for a transplant- related or transplant-unrelated problem.
Currently, the risk of rejection is inferred from clinical and laboratory evidence of organ dysfunction. The assessed risk is then used to guide treatment planning, and evaluate whether this planned treatment affects other transplant-related care.
Occasionally, transplant rejection can occur without evidence of organ dysfunction. However, organ dysfunction can also occur due to infections or mechanical causes and not rejection. The only definitive method to assess whether rejection is happening is an invasive biopsy. Biopsies can cause serious complications such as bleeding or perforation. The PleximmuneTM blood test provides information about whether the risk of rejection is increased or decreased. This information can be combined with available clinical information to develop a treatment plan.